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Microstructural Kinetics Group

Department of Materials Science & Metallurgy
 
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This is a superlist combining all those seminars on talks.cam taking place in one of the Departments of the School of Physical sciences, plus occasional other talks which would be of significant interest to researchers in the School. If you would like your talk or list included please contact Duncan (drs45)
Updated: 4 min 3 sec ago

Wed 17 Nov 14:00: Title to be confirmed

Tue, 05/10/2021 - 12:50
Title to be confirmed

Abstract not available

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Fri 08 Oct 16:00: D to K semileptonic decays on the lattice

Tue, 05/10/2021 - 12:36
D to K semileptonic decays on the lattice

The seminar will take place via Zoom here.

Abstract:

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Fri 15 Oct 16:00: TBA - Michael Trott

Tue, 05/10/2021 - 12:36
TBA - Michael Trott

TBA

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Fri 22 Oct 16:00: TBA - Luca Mantani

Tue, 05/10/2021 - 12:36
TBA - Luca Mantani

Abstract not available

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Fri 29 Oct 16:00: TBA - Bernhard Mistlberger

Tue, 05/10/2021 - 12:36
TBA - Bernhard Mistlberger

Abstract not available

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Fri 05 Nov 16:00: TBA - Stefania Gori

Tue, 05/10/2021 - 12:36
TBA - Stefania Gori

Abstract not available

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Fri 12 Nov 16:00: TBA - Peter Stangl

Tue, 05/10/2021 - 12:36
TBA - Peter Stangl

Abstract not available

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Fri 19 Nov 16:00: TBA - Andreas Vogt

Tue, 05/10/2021 - 12:36
TBA - Andreas Vogt

Abstract not available

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Wed 02 Mar 14:00: Transmissible cancers: when cancer cells become infectious agents Our intention is to deliver all Seminars in person, we will follow University Covid Guidance on this. Seminars are aimed mainly at MPhil CompBio students, but are open...

Tue, 05/10/2021 - 12:34
Transmissible cancers: when cancer cells become infectious agents

Cancer arises when mutations drive cells of the body to abandon their usual functions and to instead embark upon a “selfish” evolutionary programme underpinned by abnormal growth. Most cancers exist only within the bodies of the hosts that spawn them; rarely, however, cancers can acquire adaptations allowing them to spread between individuals. In such transmissible cancers the cancer cells themselves become agents of infection. Elizabeth Murchison will discuss recent research on the origins and evolution of the naturally occurring mammalian transmissible cancers affecting dogs and Tasmanian devils.

Our intention is to deliver all Seminars in person, we will follow University Covid Guidance on this. Seminars are aimed mainly at MPhil CompBio students, but are open to anyone who wishes to attend by pre-booking with the Administrator

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Wed 09 Feb 14:00: Drug Discovery in the era of large-scale genetics and genomics data Our intention is to deliver all Seminars in person, we will follow University Covid Guidance on this. Seminars are aimed mainly at MPhil CompBio students, but are...

Tue, 05/10/2021 - 12:31
Drug Discovery in the era of large-scale genetics and genomics data

Drug discovery remains a very long and costly process with reducing attrition a major objective. We have shown previously that using human genetics evidence may increase the chance of success in the clinic for drug targets. In addition, functional genomics technologies that can measure or perturb the genome at scale can also be used to identify and validate new drug targets, support patient stratification or understanding of mechanism of action. In this talk, using examples. I will describe how the combination of large scale genetics and functional genomics data combined with analytics is impacting drug discovery.

Our intention is to deliver all Seminars in person, we will follow University Covid Guidance on this. Seminars are aimed mainly at MPhil CompBio students, but are open to anyone who wishes to attend by pre-booking with the Administrator

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Wed 26 Jan 14:00: Computational image analysis for coeliac disease diagnosis Our intention is to deliver all Seminars in person, we will follow University Covid Guidance on this. Seminars are aimed mainly at MPhil CompBio students, but are open to...

Tue, 05/10/2021 - 12:28
Computational image analysis for coeliac disease diagnosis

The discipline of image analysis has grown over the last decade, and machine learning, deep learning and artificial intelligence (AI) techniques are now being used for many real-world image analysis tasks. In the first part of this seminar, I will give an overview of some of the tools used when studying medical images. One application is the diagnosis of coeliac disease: from an image of a duodenal biopsy, how can we use computational tools to determine whether of not there is evidence of coeliac disease? Biopsies are complicated and the variation between different images is huge, so analysing them in an automated fashion is a challenging task. In the second part of the seminar, I will share some of the difficulties involved and show some early results of our research.

Our intention is to deliver all Seminars in person, we will follow University Covid Guidance on this. Seminars are aimed mainly at MPhil CompBio students, but are open to anyone who wishes to attend by pre-booking with the Administrator

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Wed 19 Jan 14:00: Bioinformatic analysis of T-cell antigen receptors as a novel diagnostic test for coeliac disease/ gluten sensitivity Our intention is to deliver all Seminars in person, we will follow University Covid Guidance on this. Seminars are...

Tue, 05/10/2021 - 11:51
Bioinformatic analysis of T-cell antigen receptors as a novel diagnostic test for coeliac disease/ gluten sensitivity

Coeliac disease presents with very variable symptoms, which occur when gluten is eaten. It affects at least 1% of the UK population and more than 2/3 affected individuals remain undiagnosed, often because current tests give uncertain or false negative results or are unacceptable to patients, due to the requirement prior to testing to eat gluten, which makes them ill. Coeliac disease is caused by T-cell mediated injury to the epithelial lining of the intestine, with many of the T-cells responding to gluten. Holistic analysis of the T-cell receptor nucleic acid/ amino acid sequences in patient samples allows us to compare the T-cell populations, to determine whether they are responding to similar or different immunological targets. Provided there is a sufficiently sized training set for this artificial intelligence based, bioinformatic approach, patient samples can be separated by diagnosis, regardless of whether the patient has eaten gluten prior to the test. This approach can also be used in the diagnosis of inflammatory bowel disease and a range of other immune-mediated conditions, as well as to determine immune status to antigens post-vaccination. We are currently testing its applicability to the determination of an individual’s COVID -19 immune status. Analysis of T-cell receptors is a powerful and widely used tool. The bioinformatic approaches used will be discussed.

Our intention is to deliver all Seminars in person, we will follow University Covid Guidance on this. Seminars are aimed mainly at MPhil CompBio students, but are open to anyone who wishes to attend by pre-booking with the Administrator.

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Wed 03 Nov 16:00: The topology of the Gelfand–Zeitlin fiber

Mon, 04/10/2021 - 18:05
The topology of the Gelfand–Zeitlin fiber

Gelfand–Zeitlin systems are a well-known family of examples in symplectic geometry, singular Lagrangian torus fibrations whose total spaces are coadjoint orbits of an action of a unitary or special orthogonal group and whose base spaces are certain convex polytopes. They are easily defined in terms of matrices and their truncations, but do not fit into the familiar framework of integrable systems with nondegenerate singularities, and hence are studied as a sort of edge case.

It is known that the fibers of these systems are determined as iterated pullbacks by the combinatorics of joint eigenvalues of systems of truncated matrices, but the resulting expressions can be rather inexplicit. We provide a new interpretation of Gelfand–Zeitlin fibers as balanced products of Lie groups (or biquotients), and pursue these viewpoints to a determination of their cohomology rings and low-dimensional homotopy groups which can be read transparently off of the combinatorics.

This all represents joint work with Jeremy Lane.

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Tue 12 Oct 14:30: Recent progress on the formal degree conjecture

Mon, 04/10/2021 - 16:55
Recent progress on the formal degree conjecture

The local Langlands correspondence is more than a bijective correspondence: it promises an extensive dictionary between the representation theory of reductive p-adic groups and the arithmetic of their L-parameters. One entry in this dictionary is a conjectural formula of Hiraga, Ichino, and Ikeda for the size of a discrete series representation—its “formal degree”—in terms of a gamma factor of its L-parameter. In this talk, I’ll explain why the conjecture is true for almost all supercuspidal representations. Time permitting, I’ll also compute the sign of the gamma factor, verifying a conjecture of Gross and Reeder.

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Fri 08 Oct 16:00: D to K semileptonic decays on the lattice

Sun, 03/10/2021 - 07:58
D to K semileptonic decays on the lattice

The seminar will take place via Zoom here.

Abstract:

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Fri 15 Oct 16:00: TBA - Michael Trott

Sun, 03/10/2021 - 07:58
TBA - Michael Trott

TBA

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Fri 22 Oct 16:00: TBA - Luca Mantani

Sun, 03/10/2021 - 07:58
TBA - Luca Mantani

Abstract not available

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Fri 29 Oct 16:00: TBA - Bernhard Mistlberger

Sun, 03/10/2021 - 07:58
TBA - Bernhard Mistlberger

Abstract not available

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